PMID: 10531064

 

    Legend: Sugar

Title : Crystal structure of the ectodomain of human transferrin receptor

Abstract :
  1. The transferrin receptor ( TfR ) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin ( Tf ) and recycling apo transferrin after discharge of iron in the endosome
  2. The crystal structure of the dimeric ectodomain of the human TfR , determined here to 3.2 angstroms resolution, reveals a three-domain subunit
  3. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure
  4. A model is proposed for Tf binding to the receptor