PMID: 12297050

 

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Title : Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Abstract :

1. Epidermal growth factor ( EGF ) regulates cell proliferation and differentiation by binding to the EGF receptor ( EGFR ) extracellular region , comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase
2. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3 .3 A resolution
3. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III
4. The 1:1 EGF * EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other
5. The unique "receptor-mediated dimerization " was verified by EGFR mutagenesis