PMID: 1421757

 

    Legend: Sugar

Title : Identification of the O-linked glycosylation site of the human transferrin receptor

Abstract :

1. The human transferrin receptor is a glycoprotein containing three N-linked and one O-linked glycosylation sites
2. Tryptic digestion of the receptor , followed by chromatography on BioGel P-2 and reverse-phase HPLC, yields a glycopeptide (amino acids 101-120) containing the O-linked site
3. Amino acid sequence analysis reveals that the site of O-glycosylation is Thr-104
4. Mass spectral analysis is consistent with the presence of a Gal-GalNAc core with predominantly two sialic acid residues.