Title : The islet-specific
glucose-6-phosphatase-related protein, implicated in diabetes, is a
glycoprotein embedded in the endoplasmic reticulum membrane
Abstract :
- The islet-specific glucose-6-phosphatase-related protein ( IGRP ) has no known catalytic activity, but is of interest because it is the source of the peptide autoantigen targeted by a prevalent population of pathogenic CD8(+) T cells in non-obese diabetic mice
- To better understand the potential roles of this protein in diabetes mellitus, we examine the subcellular localization and membrane topography of human IGRP
- We show that IGRP is a glycoprotein , held in the endoplasmic reticulum by nine transmembrane domains , which is degraded in cells predominantly through the proteasome pathway that generates the major histocompatibility complex class I-presented peptides