PMID: 15961631

 

    Legend: Sugar

Title : Crystal structure of human toll-like receptor 3 ( TLR3 ) ectodomain

Abstract :

1. Toll-like receptors ( TLRs ) play key roles in activating immune responses during infection
2. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats leucine-rich repeats (LRRs)
3. Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization
4. TLR3 is largely masked by carbohydrate , but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization
5. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA