PMID: 16166642

 

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Title : JAMP , a Jun N-terminal kinase 1 ( JNK1 )-associated membrane protein , regulates duration of JNK activity

Abstract :
  1. We report the identification and characterization of JAMP ( JNK1 [ Jun N-terminal kinase 1]-associated membrane protein ), a predicted seven-transmembrane protein that is localized primarily within the plasma membrane and associates with JNK1 through its C-terminal domain
  2. JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5 , resulting in increased and prolonged JNK1 activity following stress
  3. Elevated expression of JAMP following UV or tunicamycin treatment results in sustained JNK activity and a higher level of JNK-dependent apoptosis
  4. Inhibition of JAMP expression by RNA interference reduces the degree and duration of JNK activation and concomitantly the level of stress-induced apoptosis
  5. Through its regulation of JNK1 activity, JAMP emerges as a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli