Title : JAMP , a Jun N-terminal kinase 1 ( JNK1 )-associated membrane protein , regulates duration of JNK activity
Abstract :
We report the identification and characterization of JAMP ( JNK1 [ Jun N-terminal kinase 1]-associated membrane protein ), a predicted seven-transmembrane protein that is localized primarily within the plasma membrane and associates with JNK1 through its C-terminal domain
JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5 , resulting in increased and prolonged JNK1 activity following stress
Elevated expression of JAMP following UV or tunicamycin treatment results in sustained JNK activity and a higher level of JNK-dependent apoptosis
Inhibition of JAMP expression by RNA interference reduces the degree and duration of JNK activation and concomitantly the level of stress-induced apoptosis
Through its regulation of JNK1 activity, JAMP emerges as a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli