PMID: 16186819

 

    Legend: Sugar

Title : Structure of the calcium-rich signature domain of human thrombospondin-2

Abstract :
  1. Thrombospondins ( THBSs ) are secreted glycoproteins that have key roles in interactions between cells and the extracellular matrix
  2. Here, we describe the 2.6-A-resolution crystal structure of the glycosylated signature domain of human THBS2 , which includes three epidermal growth factor-like modules, 13 aspartate-rich repeats and a lectin-like module
  3. These elements interact extensively to form three structural regions termed the stalk, wire and globe
  4. The THBS2 signature domain is stabilized by these interactions and by a network of 30 bound Ca(2 +) ions and 18 disulfide bonds
  5. The structure suggests how genetic alterations of THBSs result in disease