Title : An improved resolution structure of the human beta common
receptor involved in
IL-3 ,
IL-5 and
GM-CSF signalling which gives better definition of the high-affinity binding
epitope
Abstract :
- X-ray diffraction has been used to produce and refine a model of the extracellular domains of the beta common cytokine receptor
- A minor improvement in resolution has resulted in improved electron-density maps, which have given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule