Title : Ligands bind to
Sortilin in the tunnel of a ten-bladed beta-propeller
domain
Abstract :
- The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain
- Binding competition studies suggest that additional binding sites , for example, for the prodomain of nerve growth factor-beta , are present in the tunnel and that competition for binding relates to the restricted space inside the propeller