PMID: 19122660

 

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Title : Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

Abstract :
  1. The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain
  2. Binding competition studies suggest that additional binding sites , for example, for the prodomain of nerve growth factor-beta , are present in the tunnel and that competition for binding relates to the restricted space inside the propeller