PMID: 19508227

 

    Legend: Sugar

Title : Glycosylation of tetraspanin Tspan-1 at four distinct sites promotes its transition through the endoplasmic reticulum

Abstract :

1. We showed that Tspan-1 , a tetraspanin overexpressed in many human cancers, harbours oligosaccharides at all four potential N-glycosylation sites.
2. Its most abundant form contained only mannose-rich sugar chains but two distinct glycosylation sites could also contain complex carbohydrates
3. Glycosylation seemed to be required for correct folding and subsequent transition through the endoplasmic reticulum