PMID: 19651138

 

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Title : Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

Abstract :

1. Ionotropic glutamate receptors are functionally diverse but have a common architecture, including the 400-residue amino-terminal domain ( ATD )
2. We report a 1.8-A resolution crystal structure of human GluR2- ATD
3. This dimeric structure provides a mechanism for how the ATDs can drive receptor assembly and subtype-restricted com position
4. Lattice contacts in a 4.1-A resolution crystal form reveal a tetrameric (dimer-dimer) arrangement consistent with previous cellular and cryo-electron microscopic data for full-length AMPA receptors