Title :
PANP is a novel O-glycosylated
PILRα ligand expressed in neural tissues
Abstract :
- PILRα is an immune inhibitory receptor possessing an immuno receptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain enabling it to deliver inhibitory signals
- Binding of PILRα to its ligand CD99 is involved in immune regulation; however, whether there are other PILRα ligands in addition to CD99 is not known
- Here, we report that a novel molecule, PILR-associating neural protein ( PANP ), acts as an additional ligand for PILRα.
- Transcription of PANP was mainly observed in neural tissues
- PILRα- Ig fusion protein bound cells transfected with PANP and the transfectants stimulated PILRα reporter cells
- Specific O-glycan structures on PANP were found to be required for PILR recognition of this ligand
- These results suggest that PANP is involved in immune regulation as a ligand of the PILRα.