PMID: 2137200

 

    Legend: Sugar

Title : Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Abstract :
  1. Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes
  2. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein
  3. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist