Title : Amino acid
sequence of
CAP37 , a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic
glycoprotein structurally similar to
neutrophil elastase
Abstract :
- We report the amino acid sequence of CAP37 , a human neutrophil granule protein with antibacterial and monocyte-specific chemotactic activity
- CAP37 is a single-chain protein consisting of 222 amino acid residues
- It has three N-glycosylation sites , at Asn residues 100, 114 and 145
- Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145
- CAP37 has 45% sequence identity to human neutrophil elastase , and 30-37% identity to several other granule serine proteinases
- Despite these similarities, CAP37 is not a serine proteinase because the active site residues serine and histidine are replaced