PMID: 2226832

 

    Legend: Sugar

Title : Amino acid sequence of CAP37 , a human neutrophil granule-derived antibacterial and monocyte-specific chemotactic glycoprotein structurally similar to neutrophil elastase

Abstract :
  1. We report the amino acid sequence of CAP37 , a human neutrophil granule protein with antibacterial and monocyte-specific chemotactic activity
  2. CAP37 is a single-chain protein consisting of 222 amino acid residues
  3. It has three N-glycosylation sites , at Asn residues 100, 114 and 145
  4. Some species of CAP37 are glycosylated at all three sites; some at Asn-114 alone, others at Asn-114 and Asn-110 or Asn-145
  5. CAP37 has 45% sequence identity to human neutrophil elastase , and 30-37% identity to several other granule serine proteinases
  6. Despite these similarities, CAP37 is not a serine proteinase because the active site residues serine and histidine are replaced