Title : Structures of human
acetylcholinesterase in complex with pharmacologically important ligands
Abstract :
- Human acetylcholinesterase ( AChE ) is a significant target for therapeutic drugs
- Here we present high resolution crystal structures of human AChE , alone and in complexes with drug ligands; donepezil, an Alzheimer's disease drug, binds differently to human AChE than it does to Torpedo AChE
- These crystals of human AChE provide a more accurate platform for further drug development than previously available