Title :
structure of Slitrk2-PTPδ complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
Abstract :
- Selective binding between pre- and postsynaptic adhesion molecules can induce synaptic differentiation
- Here we report the crystal structure of a synaptogenic trans-synaptic adhesion complex between Slit and Trk-like family member 2 (Slitrk2 ) and receptor protein tyrosine phosphatase ( RPTP ) δ
- The structure and site-directed mutational analysis revealed the structural basis of splicing-dependent adhesion between Slitrks and type IIa RPTPs for inducing synaptic differentiation