Title : Human
insulin receptor and its relationship to the
tyrosine kinase family of oncogenes
Abstract :
- We have deduced the entire 1,370-amino-acid sequence of the human insulin receptor precursor from a single complementary DNA clone
- The precursor starts with a 27-amino-acid signal sequence , followed by the receptor alpha- subunit , a precursor processing enzyme cleavage site , then the beta- subunit containing a single 23-amino-acid transmembrane sequence
- There are sequence homologies to human epidermal growth factor receptor and the members of the src family of oncogene products