Title : Cryo-EM structure of the polycystin 2-l1 ion channel
Abstract :
We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 ( polycystin 2-l1 ) ion channel
Encoded by PKD2L1 , polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes
The related primary cilium-specific polycystin-2 protein , encoded by PKD2 , shares a high degree of sequence similarity, yet has distinct permeability characteristics
Here we show that these differences are reflected in the architecture of polycystin 2-l1