Title : Complete amino acid sequence of human serum cholinesterase
Abstract :
The complete amino acid sequence of human serum cholinesterase ( choline esterase II (unspecific), EC 3.1.1.8) was determined by Edman degradation of purified peptides
The protein contains 574 amino acids per subunit and nine carbohydrate chains attached to 9 asparagines
The four subunits of cholinesterase appear to be identical
The active site serine is the 198th residue from the amino terminus
The sequence of human serum cholinesterase is 53.8% identical with the sequence of acetylcholinesterase from Torpedo californica and 28% identical with the carboxyl-terminal portion of bovine thyroglobulin