PMID: 3550808

 

    Legend: Sugar

Title : Primary structure of human neutrophil elastase

Abstract :
  1. The complete amino acid sequence of human neutrophil elastase has been determined
  2. The protein consists of 218 amino acid residues , contains two asparagine-linked carbohydrate side chains asparagine-linked carbohydrate side chains, and is joined together by four disulfide bonds
  3. Comparison of the sequence to other serine proteinases indicates only moderate homology with porcine pancreatic elastase (43.0%) or neutrophil cathepsin G (37.2%)
  4. In particular, many of the residues suggested to play important roles in the mechanism by which the pancreatic elastase functions are significantly changed in the neutrophil enzyme , indicating alternative types of binding with the human proteinase