Title : Complete amino acid
sequence of a mouse mu chain: homology among heavy chain constant region
domains
Abstract :
- The complete amino acid sequence of the mouse mu chain secreted by the MOPC 104E myeloma tumor has been determined
- There are four constant region domains in the mu chain and a 20-residue COOH-terminal segment that plays a role in the polymerization of pentameric immunoglobulin M molecules
- There are six sites of carbohydrate attachment in the MOPC 104E mu chain
- Three complex-type and two high-mannose oligosaccharides are located in the mu chain constant region
- The general type and location of carbohydrate moieties in the mu chain constant region are completely conserved between mouse and human mu chains
- Homology in the location of carbohydrate structures on different classes of heavy chains is discussed