Title : Amino acid
sequence of rat
alpha-lactalbumin : a unique
alpha-lactalbumin
Abstract :
- The amino acid sequence of rat alpha-lactalbumin has been determined
- Unlike other alpha-lactalbumins which contain 122 or 123 amino acids, rat alpha-lactalbumin is unique in that it contains 140 amino acids
- The extra amino acids are a 17 amino acid extension at the carboxyl terminus
- The amino acid sequence of this extension is Gly124-Ala-Pro-Ala-Leu-Val-Val130-Pro-Ala-Leu-Asp-Gly135-Glu-Thr-Pro-Val-Pro140
- The extension is proline rich, which may contribute to the anomalous structural properties of rat alpha-lactalbumin
- The amino acid sequence from residues 1 to 123 is similar to that of other alpha-lactalbumins
- One possible explanation for the 17 amino acid extension is a mutation at the termination codon