Title : The structure of an intermediate in class II MHC maturation:
CLIP bound to
HLA-
DR3
Abstract :
- A complex between HLA- DR3 and a fragment of invariant chain called CLIP was isolated from a human cell line defective in antigen presentation and its X-ray crystal structure determined
- Previous data indicate that this complex is an intermediate in class II histocompatibility maturation, occurring between invariant chain- DR3 and antigenic peptide- DR3 complexes
- The structure shows that the CLIP fragment binds to DR3 in a way almost identical to that in which antigenic peptides bind class II histocompatibility glycoproteins
- The structure is the substrate for the loading of antigenic peptides by an exchange process catalysed by DM