Title : Crystal structure of the human high-affinity
IgE receptor
Abstract :
- Allergic responses result from the activation of mast cells by the human high-affinity IgE receptor
- IgE-mediated allergic reactions may develop to a variety of environmental compounds, but the initiation of a response requires the binding of IgE to its high-affinity receptor
- We have solved the X-ray crystal structure of the antibody-binding domains of the human IgE receptor at 2.4 A resolution
- The structure reveals a highly bent arrangement of immunoglobulin domains that form an extended convex surface of interaction with IgE
- A prominent loop that confers specificity for IgE molecules extends from the receptor surface near an unusual arrangement of four exposed tryptophans
- The crystal structure of the IgE receptor provides a foundation for the development of new therapeutic approaches to allergy treatment