Title : Crystal structure of the
ectodomain of human
transferrin receptor
Abstract :
- The transferrin receptor ( TfR ) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin ( Tf ) and recycling apo transferrin after discharge of iron in the endosome
- The crystal structure of the dimeric ectodomain of the human TfR , determined here to 3.2 angstroms resolution, reveals a three-domain subunit
- One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure
- A model is proposed for Tf binding to the receptor
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
- 0. transferrin receptor, ectodomain
- 2. TfR, ectodomain
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):