PMID: 10930422

 

    Legend: Gene, Sites

Title : Reprimo , a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

Abstract :

1. A novel gene, Reprimo , in which induction in cells exposed to X-irradiation is dependent on p53 expression, has been isolated
2. Ectopic p53 expression results in the induction of its mRNA
3. Reprimo is a highly glycosylated protein and, when ectopically expressed, it is localized in the cytoplasm and induces G(2) arrest of the cell cycle
4. In the arrested cells, both Cdc2 activity and nuclear translocation of cyclin B1 are inhibited, suggesting the involvement of Reprimo in the Cdc2 . cyclin B1 regulation pathway
5. Thus, Reprimo may be a new member involved in the regulation of p53-dependent G(2) arrest of the cell cycle

Output (sent_index, trigger, protein, sugar, site):

• 3. glycosylated, , Reprimo, -, -
• 3. glycosylated, , protein, -, -

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
cyclin B1	891	4
Thus, Reprimo	56475	5
Reprimo	56475	0,1,3,4
Ectopic p53	7157	2
Cdc2	983	4
p53	7157	0,1,5