Title : Crystal structure of human
PEDF , a potent anti-angiogenic and neurite growth-promoting
factor
Abstract :
- Pigment epithelium-derived factor ( PEDF ), a noninhibitory member of the serpin superfamily, is the most potent inhibitor of angiogenesis in the mammalian ocular compartment
- It also has neurotrophic activity, both in the retina and in the central nervous system, and is highly up-regulated in young versus senescent fibroblasts
- To provide a structural basis for understanding its many biological roles, we have solved the crystal structure of glycosylated human PEDF to 2.85 A
- The structure revealed the organization of possible receptor and heparin-binding sites , and showed that, unlike any other previously characterized serpin , PEDF has a striking asymmetric charge distribution that might be of functional importance
- These results provide a starting point for future detailed structure/function analyses into possible mechanisms of PEDF action that could lead to development of therapeutics against uncontrolled angiogenesis
Output (sent_index, trigger,
protein,
sugar,
site):
- 3. glycosylated, , PEDF, -, -
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):