PMID: 12034737

 

    Legend: Gene, Sites

Title : The role of post-translational modifications of the CXCR4 amino terminus in stromal-derived factor 1 1 alpha association and HIV-1 entry

Abstract :

1. The chemokine receptor CXCR4 plays critical roles in development, immune function, and human immunodeficiency virus type 1 (HIV-1) entry
2. Here we demonstrate that, like the CC-chemokine receptors CCR5 and CCR2b , CXCR4 is posttranslationally modified by sulfation of its amino-terminal tyrosines
3. The sulfate group at tyrosine 21 contributes substantially to the ability of CXCR4 to bind its ligand, stromal derived factor 1 1 alpha
4. Tyrosine sulfation plays a less significant role in CXCR4-dependent HIV-1 entry than in CCR5-dependent HIV-1 entry
5. In some cell lines, CXCR4 is efficiently modified by a chondroitin sulfate chain at serine 18 , but neither HIV-1 entry nor stromal derived factor 1 1 alpha binding was affected by loss of this glycosaminoglycan
6. These data demonstrate a functional role for tyrosine sulfate in the CXC-chemokine receptor family and underscore a general difference in HIV-1 utilization of CCR5 and CXCR4

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 0. CXCR4, terminus

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
CCR2b	729230	2
CCR5	1234	2,4,6
CXCR4	7852	0,1,2,3,4,5,6