PMID: 12297050

 

    Legend: Gene, Sites

Title : Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

Abstract :

1. Epidermal growth factor ( EGF ) regulates cell proliferation and differentiation by binding to the EGF receptor ( EGFR ) extracellular region , comprising domains I-IV, with the resultant dimerization of the receptor tyrosine kinase
2. In this study, the crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3 .3 A resolution
3. EGFR domains I-III are arranged in a C shape, and EGF is docked between domains I and III
4. The 1:1 EGF * EGFR complex dimerizes through a direct receptor*receptor interaction, in which a protruding beta-hairpin arm of each domain II holds the body of the other
5. The unique "receptor-mediated dimerization " was verified by EGFR mutagenesis

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 1. EGF receptor, region
• 2. EGF, region
• 2. EGFR, region
• 3. EGFR, domains

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
epidermal growth factor	1950	0
EGFR	1956	1,2,3,4,5
1:1 EGF	1950	4
EGF receptor	1956	1
Epidermal growth factor	1950	1
EGF	1950	1,2,3