Title :
structure of the Nogo receptor ectodomain : a recognition module implicated in myelin inhibition
Abstract :
- Failure of axon regeneration in the adult mammalian central nervous system (CNS) is at least partly due to inhibitory molecules associated with myelin
- Recent studies suggest that an axon surface protein , the Nogo receptor ( NgR ), may play a role in this process through an unprecedented degree of crossreactivity with myelin-associated inhibitory ligands
- Here, we report the 1.5 A crystal structure and functional characterization of a soluble extracellular domain of the human Nogo receptor
- Nogo receptor adopts a leucine-rich repeat (LRR) module whose concave exterior surface contains a broad region of evolutionarily conserved patches of aromatic residues , possibly suggestive of degenerate ligand binding sites
- A deep cleft at the C-terminal base of the LRR may play a role in NgR association with the p75 coreceptor
- These results now provide a detailed framework for focused structure-function studies aimed at assessing the physiological relevance of NgR-mediated protein- protein interactions to axon regeneration inhibition
Output (sent_index, trigger,
protein,
sugar,
site):
- 4. leucine-rich, , -, LRR, leucine
- 4. leucine-rich, , -, a leucine-rich repeat, leucine
Output(Part-Of) (sent_index,
protein,
site):
- 0. structure of the Nogo receptor, ectodomain
- 3. Nogo receptor, domain
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):