PMID: 12925274

 

    Legend: Gene, Sites

Title : structure of the semaphorin-3A receptor binding module

Abstract :

1. The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance
2. Their distinctive feature is a conserved 500 amino acid semaphorin domain , a ligand-receptor interaction module also present in plexins and scatter-factor receptors
3. We report the crystal structure of a secreted 65 kDa form of Semaphorin-3A ( Sema3A ), containing the full semaphorin domain
4. Unexpectedly, the semaphorin fold is a variation of the beta propeller topology
5. Analysis of the Sema3A structure and structure-based mutagenesis data identify the neuropilin binding site and suggest a potential plexin interaction site
6. Based on the structure, we present a model for the initiation of semaphorin signaling and discuss potential similarities with the signaling mechanisms of other beta propeller cell surface receptors , such as integrins and the LDL receptor

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 3. form of Semaphorin-3A, domain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
Sema3A	10371	3,5
form of Semaphorin-3A	10371	3
LDL receptor	3949	6
structure of the semaphorin-3A	10371	0