PMID: 1451807

 

    Legend: Gene, Sites

Title : Natural human tumor necrosis factor beta ( lymphotoxin )

Abstract :

1. Variable O-glycosylation at Thr7 , proteolytic processing, and allelic variation
2. Natural human tumor necrosis factor beta ( TNF-beta ) purified from supernatants of a human B-lymphoblastoid cell line was found to be heterogeneous in molecular mass, with seven components resolved by gel electrophoresis
3. All components are N-glycosylated at Asn62 ; N-glycosylation does not contribute to heterogeneity
4. In addition, part of the molecules are O-glycosylated at Thr7 ; O-glycosylation is heterogeneous due to variable decoration with neuraminic acid
5. The four lower molecular mass forms are derived from the full-length protein by trypsin-like proteolytic cleavage in the N-proximal region ; these clipped molecules lack O-linked carbohydrates
6. Two allelic variants differing in amino acid position 26 (threonine/asparagine) were identified

Output (sent_index, trigger, protein, sugar, site):

• 1. O-glycosylation, , -, -, Thr7
• 3. N-glycosylated, , -, All components, Asn62
• 4. O-glycosylated, , -, -, Thr7

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

• 1. tumor necrosis factor beta, -, Thr7
• 3. tumor necrosis factor beta, All components, Asn62
• 4. tumor necrosis factor beta, -, Thr7

 

Protein	NCBI ID	SENTENCE INDEX
tumor necrosis factor beta	4049	0,2