Title : The islet-specific glucose-6-phosphatase-related protein, implicated in diabetes, is a
glycoprotein embedded in the endoplasmic reticulum membrane
Abstract :
- The islet-specific glucose-6-phosphatase-related protein ( IGRP ) has no known catalytic activity, but is of interest because it is the source of the peptide autoantigen targeted by a prevalent population of pathogenic CD8(+) T cells in non-obese diabetic mice
- To better understand the potential roles of this protein in diabetes mellitus, we examine the subcellular localization and membrane topography of human IGRP
- We show that IGRP is a glycoprotein , held in the endoplasmic reticulum by nine transmembrane domains , which is degraded in cells predominantly through the proteasome pathway that generates the major histocompatibility complex class I-presented peptides
Output (sent_index, trigger,
protein,
sugar,
site):
- 0. glycoprotein, , glycoprotein, -, -
- 3. glycoprotein, , IGRP, -, -
- 3. glycoprotein, , glycoprotein, -, -
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):