PMID: 15099525

 

    Legend: Gene, Sites

Title : Structural basis for dimerization of ICAM-1 on the cell surface

Abstract :

1. We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1
2. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed
3. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5
4. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane
5. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell ( APC ) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 1. ICAM-1, domains
• 2. ICAM-1, fragment

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
ICAM-3	3385	3
ICAM-1	3383	0,1,2,5
ICAM-1 cis	3383	4
ICAM-5	7087	3