PMID: 15961631

 

    Legend: Gene, Sites

Title : Crystal structure of human toll-like receptor 3 ( TLR3 ) ectodomain

Abstract :

1. Toll-like receptors ( TLRs ) play key roles in activating immune responses during infection
2. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs)
3. Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization
4. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization
5. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA

Output (sent_index, trigger, protein, sugar, site):

• 2. leucine-rich, , -, 23 leucine-rich repeats, leucine

Output(Part-Of) (sent_index, protein, site):

• 0. toll-like receptor 3, ectodomain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX