PMID: 16043704

 

    Legend: Gene, Sites

Title : The molecular structure of the Toll-like receptor 3 ligand-binding domain

Abstract :

1. Innate immunity is the first line of defense against invading pathogens
2. Toll-like receptors ( TLRs ) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA through their ligand-binding domain that is composed of leucine-rich repeats (LRRs)
3. Ligand binding initiates a signaling cascade that leads to the up-regulation of inflammation mediators
4. In this study, we have expressed and crystallized the ectodomain ( ECD ) of human TLR3 , which recognizes dsRNA, a molecular signature of viruses, and have determined the molecular structure to 2.4-A resolution
5. The overall horseshoe-shaped structure of the TLR3- ECD is formed by 23 repeating LRRs that are capped at each end by specialized non-LRR domains
6. The extensive beta-sheet on the molecule's concave surface forms a platform for several modifications, including insertions in the LRRs and 11 N-linked glycans
7. The TLR3- ECD structure indicates how LRR loops can establish distinct pathogen recognition receptors

Output (sent_index, trigger, protein, sugar, site):

• 2. leucine-rich, , -, leucine-rich repeats, leucine

Output(Part-Of) (sent_index, protein, site):

• 4. TLR3, ectodomain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX