PMID: 16234806

 

    Legend: Gene, Sites

Title : Cbln1 is essential for synaptic integrity and plasticity in the cerebellum

Abstract :

1. Cbln1 is a cerebellum-specific protein of previously unknown function that is structurally related to the C1q and tumor necrosis factor families of proteins
2. We show that Cbln1 is a glycoprotein secreted from cerebellar granule cells that is essential for three processes in cerebellar Purkinje cells: the matching and maintenance of pre- and postsynaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses
3. Notably, the phenotype of cbln1-null mice mimics loss-of-function mutations in the orphan glutamate receptor , GluR delta2 , a gene selectively expressed in Purkinje neurons
4. Therefore, Cbln1 secreted from presynaptic granule cells may be a component of a transneuronal signaling pathway that controls synaptic structure and plasticity

Output (sent_index, trigger, protein, sugar, site):

• 2. glycoprotein, , Cbln1, -, -
• 2. glycoprotein, , glycoprotein, -, -

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
C1q	12259	1