PMID: 16492764

 

    Legend: Gene, Sites

Title : Homodimeric cross-over structure of the human granulocyte colony-stimulating factor ( GCSF ) receptor signaling complex

Abstract :

1. A crystal structure of the signaling complex between human granulocyte colony-stimulating factor ( GCSF ) and a ligand binding region of GCSF receptor ( GCSF-R ), has been determined to 2.8 A resolution
2. The GCSF : GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF
3. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6 / gp130 signaling complex
4. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 1. GCSF receptor, region
• 2. GCSF-R and GCSF, domains
• 3. GCSF, domain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
GCSF	1440	0,1,2,3
GCSF-R	1441	1,4
GCSF receptor	1441	1
granulocyte colony-stimulating factor	1440	0,1
GCSF-R and GCSF	1441	2