Title : An improved resolution structure of the human beta common
receptor involved in
IL-3 ,
IL-5 and
GM-CSF signalling which gives better definition of the high-affinity binding
epitope
Abstract :
- X-ray diffraction has been used to produce and refine a model of the extracellular domains of the beta common cytokine receptor
- A minor improvement in resolution has resulted in improved electron-density maps, which have given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
- 1. receptor, domains
- 2. -, position
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):