Title : Ligands bind to
Sortilin in the tunnel of a ten-bladed beta-propeller
domain
Abstract :
- The structure of the Sortilin ectodomain in complex with neurotensin has been determined at 2-A resolution, revealing that the C-terminal part of neurotensin binds in the tunnel of a ten-bladed beta-propeller domain
- Binding competition studies suggest that additional binding sites , for example, for the prodomain of nerve growth factor-beta , are present in the tunnel and that competition for binding relates to the restricted space inside the propeller
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
- 1. structure of the Sortilin, ectodomain
- 2. factor-beta, prodomain
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):