Title :
MRAP and
MRAP2 are bidirectional regulators of the melanocortin
receptor family
Abstract :
- The melanocortin receptor ( MCR ) family consists of 5 G protein-coupled receptors ( MC1R-MC5R ) with diverse physiologic roles
- MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis
- Mutations in MC4R are the single most common cause of monogenic obesity
- Investigating the way in which these receptors signal and traffic to the cell membrane is vital in understanding disease processes related to MCR dysfunction
- MRAP is an MC2R accessory protein , responsible for adrenal MC2R trafficking and function
- Here we identify MRAP2 as a unique homologue of MRAP , expressed in brain and the adrenal gland
- We report that MRAP and MRAP2 can interact with all 5 MCRs
- This interaction results in MC2R surface expression and signaling
- In contrast, MRAP and MRAP2 can reduce MC1R , MC3R , MC4R , and MC5R responsiveness to [Nle4,D- Phe7 ] alpha-melanocyte-stimulating hormone ( NDP- MSH )
- Collectively, our data identify MRAP and MRAP2 as unique bidirectional regulators of the MCR family
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):