PMID: 19651138

 

    Legend: Gene, Sites

Title : Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors

Abstract :

1. Ionotropic glutamate receptors are functionally diverse but have a common architecture, including the 400-residue amino-terminal domain ( ATD )
2. We report a 1.8-A resolution crystal structure of human GluR2- ATD
3. This dimeric structure provides a mechanism for how the ATDs can drive receptor assembly and subtype-restricted com position
4. Lattice contacts in a 4.1-A resolution crystal form reveal a tetrameric (dimer-dimer) arrangement consistent with previous cellular and cryo-electron microscopic data for full-length AMPA receptors

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 0. GluR2, domain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX