PMID: 20457942

 

    Legend: Gene, Sites

Title : Function of human Rh based on structure of RhCG at 2.1 A

Abstract :

1. In humans, NH(3) transport across cell membranes is facilitated by the Rh (rhesus) family of proteins
2. Human Rh C glycoprotein ( RhCG ) forms a trimeric complex that plays an essential role in ammonia excretion and renal pH regulation
3. The X-ray crystallographic structure of human RhCG , determined at 2.1 A resolution, reveals the mechanism of ammonia transport
4. Each monomer contains 12 transmembrane helices, one more than in the bacterial homologs
5. Reconstituted into proteoliposomes, RhCG conducts NH(3) to raise internal pH. Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG , RhD , and RhCE

Output (sent_index, trigger, protein, sugar, site):

• 2. glycoprotein, , Human Rh C glycoprotein, -, -
• 2. glycoprotein, , RhCG, -, -

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
Human Rh C glycoprotein	51458	2
RhCG	51458	2,3,5
RhCE	6006	5
RhAG	6005	5
structure of RhCG	51458	0
RhD	6007	5