Title : The molecular interaction of
CAR and
JAML recruits the central cell signal transducer
PI3K
Abstract :
- Coxsackie and adenovirus receptor ( CAR ) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy
- Recent discovery of the interaction between junctional adhesion molecule-like protein ( JAML ) and CAR uncovered important functional roles in immunity, inflammation, and tissue homeostasis
- Crystal structures of JAML ectodomain (2.2 angstroms) and its complex with CAR (2.8 angstroms) reveal an unusual immunoglobulin-domain assembly for JAML and a charged interface that confers high specificity
- Biochemical and mutagenesis studies illustrate how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase ( P13K ) to a JAML intracellular sequence motif as delineated for the alphabeta T cell costimulatory receptor CD28
- Thus, CAR and JAML are cell signaling receptors of the immune system with implications for asthma, cancer, and chronic nonhealing wounds
Output (sent_index, trigger,
protein,
sugar,
site):
Output(Part-Of) (sent_index,
protein,
site):
- 3. JAML, ectodomain
- 4. JAML, motif
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):