PMID: 20934432

 

    Legend: Gene, Sites

Title : Crystal structure of human interferon-λ1 in complex with its high-affinity receptor interferon-λR1

Abstract :

1. Interferon ( IFN)-λ1 [also known as interleukin ( IL)-29 ] belongs to the recently discovered group of type III IFNs
2. All type III IFNs initiate signaling processes through formation of specific heterodimeric receptor complexes consisting of IFN-λR1 and IL-10R2
3. We have determined the structure of human IFN-λ1 complexed with human IFN-λR1 , a receptor unique to type III IFNs
4. The overall structure of IFN-λ1 is topologically similar to the structure of IL-10 and other members of the IL-10 family of cytokines
5. IFN-λR1 consists of two distinct domains having fibronectin type III topology
6. The ligand- receptor interface includes helix A, loop AB, and helix F on the IFN site , as well as loops primarily from the N-terminal domain and inter-domain hinge region of IFN-λR1
7. Com position and architecture of the interface that includes only a few direct hydrogen bonds support an idea that long-range ionic interactions between ligand and receptor govern the process of initial recognition of the molecules while hydrophobic interactions finalize it

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 6. IFN-λR1, domain
• 6. IFN-λR1, region
• 6. IFN, site

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
structure of IFN-λ1	282618	4
IL)-29	282618	1
IFN-λ1	282618	3
IFN-λR1	163702	2,3,5,6
IL-10	3586	4
fibronectin	2335	5
structure of IL-10	3586	4
IFN)-λ1	282618	1
interferon-λ1 in complex	282618	0
IFN	3439	6
Interferon (	282618	1