PMID: 2136357

 

    Legend: Gene, Sites

Title : Pregnancy-associated changes in oligomannose oligosaccharides of human and bovine uromodulin ( Tamm-Horsfall glycoprotein )

Abstract :
  1. The urinary glycoprotein uromodulin ( Tamm-Horsfall glycoprotein ) exhibits a pregnancy-associated ability to inhibit antigen-specific T cell proliferation, and the activity is associated with a carbohydrate moiety [Muchmore and Decker (1985) Science 229:479-81; Hession et al., (1987) Science 237:1479-84; Muchmore, Shifrin and Decker (1987) J Immunol 138:2547-53]
  2. We report here that the Man6(7)GlcNAc2-R glycopeptides derived from uromodulin inhibit antigen-specific T cell proliferation by 50% at 0.2-2 microM, and further studies, reported elsewhere, confirm that oligomannose glycopeptides from other sources are also inhibitory, with Man9GlcNAc2-R the most inhibitory of those tested [Muchmore et al., J Leukocyte Biol (in press)]
  3. In this work, we have extended the observation of pregnancy-associated inhibitory activity to a second species, and have compared the oligomannose profile of Tamm-Horsfall glycoprotein (nonpregnant) with that of uromodulin (pregnant) derived from both human and bovine sources
  4. Surprisingly, there was a pregnancy-associated decrease in the total content of oligomannose chains due predominantly to a reduction in Man5GlcNAc2-R and Man6GlcNAc2-R
  5. Man7GlcNAc2-R, which did not decrease with pregnancy, comprised a significantly greater proportion of the total oligomannose chains in pregnant vs. nonpregnant samples from both species (human; 34.6% vs. 25.9%: bovine; 14.4% vs. 7.2%)
Output (sent_index, trigger, protein, sugar, site):
  • 0. glycoprotein, , Tamm-Horsfall glycoprotein, -, -
  • 0. glycoprotein, , uromodulin, -, -
  • 0. uromodulin, , uromodulin, oligomannose oligosaccharides, -
  • 1. glycoprotein, , Tamm-Horsfall glycoprotein, -, -
  • 1. glycoprotein, , glycoprotein, -, -
  • 1. glycoprotein, , uromodulin, -, -
  • 2. derived, , uromodulin, the Man6(7)GlcNAc2-R glycopeptides, -
  • 2. glycopeptides, , -, -, glycopeptides
  • 3. glycoprotein, , Tamm-Horsfall glycoprotein, -, -
Output(Part-Of) (sent_index, protein, site):
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX
uromodulin 7369 0,1,2,3