Title : The cataract-associated protein
TMEM114 , and
TMEM235 , are glycosylated transmembrane
proteins that are distinct from claudin family members
Abstract :
- A novel gene, TMEM114 , was annotated as a member of the claudin gene family and was subsequently associated as a cause of autosomal dominant cataract because of a translocation in its putative promoter
- Our bioinformatic and molecular analyses of TMEM114 , and the closely related TMEM235 , demonstrate that these proteins are more closely related to members of the voltage dependent calcium channel gamma subunit family
- TMEM114 and TMEM235 differed from claudins in terms of localisation in polarised epithelial cells and by the presence of N-linked glycans
- By gene expression knockdown in Xenopus tropicalis we also demonstrate a role for Tmem114 in eye development
Output (sent_index, trigger,
protein,
sugar,
site):
- 0. glycosylated, , TMEM114, -, -
- 0. glycosylated, , TMEM235, -, -
- 0. glycosylated, , proteins, -, -
Output(Part-Of) (sent_index,
protein,
site):
*Output_Site_Fusion* (sent_index,
protein,
sugar,
site):