PMID: 23520111

 

    Legend: Gene, Sites

Title : Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands

Abstract :
  1. Toll-like receptor 7 7 (TLR7 ) and TLR8 recognize single-stranded RNA and initiate innate immune responses
  2. Several synthetic agonists of TLR7- TLR8 display novel therapeutic potential; however, the molecular basis for ligand recognition and activation of signaling by TLR7 or TLR8 is largely unknown
  3. In this study, the crystal structures of unliganded and ligand-induced activated human TLR8 dimers were elucidated
  4. Ligand recognition was mediated by a dimerization interface formed by two protomers
  5. Upon ligand stimulation, the TLR8 dimer was reorganized such that the two C termini were brought into proximity
  6. The loop between leucine-rich repeat 14 (LRR14) and LRR15 was cleaved; however, the N- and C-terminal halves remained associated and contributed to ligand recognition and dimerization
  7. Thus, ligand binding induces reorganization of the TLR8 dimer , which enables downstream signaling processes
Output (sent_index, trigger, protein, sugar, site):
  • 6. leucine-rich, , -, leucine-rich repeat 14, leucine
Output(Part-Of) (sent_index, protein, site):
*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

 

Protein NCBI ID SENTENCE INDEX
7 (TLR7 51284 1
TLR8 dimer 51311 5,7
Toll-like receptor 7 51284 1
TLR7 51284 2
TLR8 dimers 51311 3
TLR8 51311 1,2