PMID: 2363690

 

    Legend: Gene, Sites

Title : A comparative study of the N-linked oligosaccharide structures of human IgG subclass proteins

Abstract :

1. Quantitative oligosaccharide profiles were determined for each of 18 human IgG paraproteins representing the four subclasses
2. Each para protein exhibits a unique profile that may be substantially different from that observed for polyclonal IgG
3. The IgG2 and some IgG3 proteins analysed exhibit a predominance of oligosaccharide moieties having galactose on the Man(alpha 1----3) arm rather than the Man(alpha 1----6) arm; it was previously held that galactosylation of the Man(alpha 1----6) arm is preferred, as observed for IgG1 , IgG4 and polyclonal IgG
4. An IgG4 protein is reported that has galactosylated Man(alpha 1----3) and Man(alpha 1----6) arms on both Fc-localized carbohydrate moieties; previous findings suggested that such fully glycosylated structures could not be accommodated within the internal space of the C gamma 2 domains
5. Unusual monoantennary oligosaccharides present in IgG2 and IgG3 proteins were isolated and their structures determined

Output (sent_index, trigger, protein, sugar, site):

• 0. proteins, , proteins, the N-linked oligosaccharide structures, -
• 3. galactose, , -, the Man(alpha 1----3) arm, -
• 3. galactose, , -, the Man(alpha 1----6) arm, -
• 5. present, , IgG2, Unusual monoantennary oligosaccharides, -
• 5. present, , IgG3 proteins, Unusual monoantennary oligosaccharides, -

Output(Part-Of) (sent_index, protein, site):

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
IgG3 proteins	3502	3,5