PMID: 25261253

 

    Legend: Gene, Sites

Title : Structural basis for the specific recognition of IL-18 by its alpha receptor

Abstract :

1. Interleukin 18 ( IL-18 ), a member of the IL-1 family of cytokines, is an important regulator of innate and acquired immune responses
2. It signals through its ligand-binding primary receptor IL-18Rα and accessory receptor IL-18Rβ.
3. Here we report the crystal structure of IL-18 with the ectodomain of IL-18Rα, which reveals the structural basis for their specific recognition
4. It confirms that surface charge complementarity determines the ligand-binding specificity of primary receptors in the IL-1 receptor family
5. We suggest that IL-18 signaling complex adopts an architecture similar to other agonistic cytokines and propose a general ligand- receptor assembly and activation model for the IL-1 family

Output (sent_index, trigger, protein, sugar, site):

Output(Part-Of) (sent_index, protein, site):

• 3. IL-18Rα,, ectodomain
• 3. structure of IL-18, ectodomain

*Output_Site_Fusion* (sent_index, protein, sugar, site):

 

Protein	NCBI ID	SENTENCE INDEX
IL-18Rα,	8809	3
IL-18	3606	0,1,5
IL-18Rα	8809	2
structure of IL-18	3606	3
IL-18Rβ.	8807	2
Interleukin 18	3606	1